AG Bewegungsstörungen und Tiefe Hirnstimulation

Einen besonderen Fokus legen wir auf die Analyse von Bildgebungsdaten, also MRT und CT-Bildern. Moderne bildgebende Verfahren ermöglichen es uns die genaue Lage der Elektroden der THS im Gehirn zu bestimmen und zu erkennen, welche neuroanatomischen Regionen und Netzwerke bei individuellen Patientinnen und Patienten stimuliert werden. So können wir herausfinden, wie die Wirkungen, aber auch mögliche Nebenwirkungen der THS entstehen. Mit diesem Wissen versuchen wir langfristig die individuelle Stimulationseinstellung jeder Patientin und jedes Patienten zu optimieren.

Häufig treten stimulationsinduzierte Sprechstörungen als Nebenwirkung der THS auf, welche für uns von besonderem Interesse sind. Bei Patientinnen und Patienten mit Bewegungsstörungen untersuchen wir inwiefern sich Sprechparameter (Stimme, Lautstärke, Artikulation, Prosodie) durch die Hirnstimulation verändern. Dafür führen wir in Kooperation mit Prof. Dr. Doris Mücke der Universität zu Köln (Phonetik) sowohl akustische als auch artikulatorische Sprechmessungen durch. Über aktuelle Forschungsergebnisse und Präsentationen im Rahmen dieser Kooperation können Sie sich auf unserer Website Brain Modulation and Speech Motor Control informieren.

Seit 2019 ist Prof. Michael Barbe Mitglied der MDS Speech and Movement Disorders Study Group und hat dadurch die Möglichkeit, in einem großen internationalen Rahmen aktuelle Forschungsprojekte voranzutreiben.

Die AG Bewegungsstörungen und Tiefe Hirnstimulation beteiligt sich an der Spezialambulanz Bewegungsstörungen zur diagnostischen und therapeutischen Mitbeurteilung von ambulanten Patientinnen und Patienten mit Bewegungsstörungen (v. a. Parkinson- und Tremorsyndrome, Dystonie, choreatiforme Störungen). Schwerpunkte sind hierbei eine „zweite Meinung“, Medikamentenoptimierung, ausführliche Aufklärung über Therapieoptionen sowie die Beratung im fortgeschrittenen Stadium auch hinsichtlich invasiver Therapieverfahren, wie z.B. die Tiefe Hirnstimulation und Medikamentenpumpen. Zudem erfolgt die ambulante Nachsorge bei bereits bestehender Tiefer Hirnstimulation in unserer Spezialambulanz.

Über das Kölner Parkinson Netzwerk (KPN) wollen wir im Dialog mit niedergelassenen Neurologinnen und Neurologen eine optimale Versorgung unserer Patientinnen und Patienten gewährleisten und aktuelle Erkenntnisse unserer Forschung in die Patientenversorgung einfließen lassen. Unser Netzwerk besteht aus ca. 30 niedergelassenen Neurologinnen und Neurologen, mit denen wir in regelmäßigem Austausch stehen und gemeinsam Fortbildungen durchführen. Die Patientinnen und Patienten haben die Möglichkeit, sich in unserer Beratungsstelle bei unserer Parkinson Nurse Susanne Hoffmann über das KPN zu informieren. Zudem organisieren wir jährlich das Seminar für Patientinnen und Patienten mit Morbus Parkinson, um eine Informationsmöglichkeit über aktuelle Forschung sowie neue und bewährte Therapien zu bieten. Termine finden Sie in unserem Veranstaltungskalender.

Die lokalen Kooperationspartner unserer Arbeitsgruppe sind die Klinik für Stereotaxie und Funktionelle Neurochirurgie (Univ.-Prof. Visser-Vandewalle), das Institut für Phonetik der Universität zu Köln (Prof. Dr. Mücke) sowie das Forschungszentrum Jülich (Prof. Dr. Tamgüney). Wir arbeiten zudem eng mit anderen Arbeitsgruppen aus der Neurologie, Psychiatrie und Nuklearmedizin zusammen sowie mit dem Studienbüro der Neurologie.

In einem aktuellen Projekt möchten wir in Kooperation mit dem Forschungszentrum Jülich eine Biodatenbank für Patientinnen und Patienten mit Parkinsonsyndromen und anderen Bewegungsstörungen aufbauen. Hierbei sammeln wir verschiedene Körperflüssigkeiten (Blut, Urin, Speichel etc.) und untersuchen diese nach möglichen Markern, die mit einer Parkinsonerkrankung assoziiert sein könnten.

2023

Wehmeyer, L., Schüller, C. B., Gruendler, T. O., Huys, D., Kuhn, J., Ullsperger, M., Visser-Vandewalle, V., Andrade, P., Baldermann, J. C., Schüller, T. (2023). Electrophysiological correlates of proactive control and binding processes during task switching in Tourette syndrome. Eneuro, 10(4). DOI: 10.1523/ENEURO.0279-22.2023

Bach, P., Luderer, M., Müller, U. J., Jakobs, M., Baldermann, J. C., Voges, J., Kiening, K., Lux, A., Visser-Vandewalle, V., Bogerts, B., Kuhn, J., Mann, K. (2023). Deep brain stimulation of the nucleus accumbens in treatment-resistant alcohol use disorder: a double-blind randomized controlled multi-center trial. Translational Psychiatry, 13(1), 49. DOI: 10.1038/s41398-023-02337-1

Jergas, H., Petry-Schmelzer, J. N., Dembek, T. A., Dafsari, H. S., Visser-Vandewalle, V., Fink, G. R., Baldermann, J. C., Barbe, M. T. (2023). Brain morphometry associated with response to levodopa and deep brain stimulation in Parkinson disease. Neuromodulation: Technology at the Neural Interface, 26(2), 340-347. DOI: 10.1016/j.neurom.2022.01.013

Peeters, J., Boogers, A., Van Bogaert, T., Dembek, T. A., Gransier, R., Wouters, J., Vandenberghe, W., De Vloo, P., Nuttin, B. ,Mc Laughlin, M. (2023). Towards biomarker-based optimization of deep brain stimulation in Parkinson's disease patients. Frontiers in Neuroscience, 16, 2316. DOI: 10.3389/fnins.2022.1091781

Jergas, H., Baldermann, J. C., Wirths, J., Barbe, M. T., Visser-Vandewalle, V., Andrade, P. (2023). Pallidal deep brain stimulation in a patient with nonketotic hyperglycemic hemichorea. Surgical Neurology International, 14. 10.25259/SNI_716_2022

Schaffrath, A., Schleyken, S., Seger, A., Jergas, H., Özdüzenciler, P., Pils, M., Blömeke, L., Cousin, A., Willbold, J., Bujnicki, T., Bannach, O., Fink, G. R., Willbold, D., Sommerauer, M., Barbe, M. T., Tamgüney, G. (2023). Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool. npj Parkinson's Disease, 9(1), 14. DO: 10.1038/s41531-023-00458-4

2022

Ganos, C., Al-Fatly, B., Fischer, J. F., Baldermann, J. C., Hennen, C., Visser-Vandewalle, V., Neudorfer, C., Martino, D., Li, J., Bouwens, T., Ackermanns, L., Leentjens, A.F.G., Pyatigorskaya, N., Worbe, Y., Fox, M.D., Kühn, A.A., Horn, A. (2022). A neural network for tics: insights from causal brain lesions and deep brain stimulation. Brain, 145(12), 4385-4397. DOI: 10.1093/brain/awac009

Strelow, J. N., Dembek, T. A., Baldermann, J. C., Andrade, P., Jergas, H., Visser-Vandewalle, V., Barbe, M. T. (2022). Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease. Brain Sciences, 12(12), 1726. DOI: 10.3390/brainsci12121726

Roediger, J., Dembek, T. A., Achtzehn, J., Busch, J. L., Krämer, A. P., Faust, K., Schneider, G.H., Krause, P., Horn, A., Kühn, A. A. (2022). Automated deep brain stimulation programming based on electrode location: a randomised, crossover trial using a data-driven algorithm. The Lancet Digital Health, 5(2), e59-e70. DOI: 10.1016/S2589-7500(22)00214-X

Pinto, S., Nebel, A., Rau, J., Espesser, R., Maillochon, P., Niebuhr, O., … Barbe, M. T., Fink, G.R., Becker, J., Reker, P., …, Deuschel, G.. (2022). Results of a Randomized Clinical Trial of Speech After Early Neurostimulation in Parkinson's Disease. Movement Disorders, 38(2), 212-222. DOI: 10.1002/mds.29282

Lowit, A., Thies, T., Steffen, J., Scheele, F., Roheger, M., Kalbe, E., Barbe, M. T. (2022). Task-based profiles of language impairment and their relationship to cognitive dysfunction in Parkinson’s disease. Plos one, 17(10), e0276218. DOI: 10.1371/journal.pone.0276218

Visser-Vandewalle, V., Andrade, P., Mosley, P. E., Greenberg, B. D., Schuurman, R., McLaughlin, N. C., ... Baldermann, J.C., … Okun, M. S. (2022). Deep brain stimulation for obsessive–compulsive disorder: a crisis of access. Nature medicine, 28(8), 1529-1532. DOI: 10.1038/s41591-022-01879-z

Baldermann, J. C., Hennen, C., Schüller, T., Andrade, P., Visser-Vandewalle, V., Horn, A., Dembek, T.A., Petry-Schmelzer, J.N., Strelow, J.N., Jergas, H., Kuhn, J., Barbe, M.T., Huys, D. (2022). Normative Functional Connectivity of Thalamic Stimulation for Reducing Tic Severity in Tourette Syndrome. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(8), 841-844. DOI: 10.1016/j.bpsc.2022.01.009

Dembek, T. A., Baldermann, J. C., Petry-Schmelzer, J. N., Jergas, H., Treuer, H., Visser-Vandewalle, V., Dafsari, H. D., Barbe, M. T. (2022). Sweetspot mapping in deep brain stimulation: strengths and limitations of current approaches. Neuromodulation: Technology at the Neural Interface, 25(6), 877-887. DOI: 10.1111/ner.13356

Petry-Schmelzer, J. N., Park, J., Haack, T. B., Visser-Vandewalle, V., Barbe, M. T., Wunderlich, G. (2022). Long-term benefit of pallidal deep brain stimulation in a patient with VPS16-associated dystonia. Neurological Research and Practice, 4(1), 1-4. DOI: 10.1186/s42466-022-00185-w

Kuhn, J., Wong, J. K., Okun, M. S., Baldermann, J. C. (2022). Connectomic imaging to predict and prevent cognitive decline after subthalamic DBS: next steps. Brain, 145(4), 1204-1206. DOI: 10.1093/brain/awac101

Jost, S. T., Strobel, L., Rizos, A., Loehrer, P. A., Ashkan, K., Evans, J., Rosenkranz, F., Barbe, M.T., Fink, G.R., Franklin, J., Sauerbier, A., Nimsky, C., Sattari, A., Ray Chaudhuri, K., Antonini, A., Timmermann, L., Martinez-Martin, P., Silverdale, M., Kalbe, E., Visser-Vandewalle, V., Dafsari, H.S. (2022). Gender gap in deep brain stimulation for Parkinson’s disease. npj Parkinson's Disease, 8(1), 47. DOI: 10.1038/s41531-022-00305-y

Roediger, J., Dembek, T. A., Wenzel, G., Butenko, K., Kühn, A. A., Horn, A. (2022). StimFit—A Data‐Driven Algorithm for Automated Deep Brain Stimulation Programming. Movement Disorders, 37(3), 574-584. DOI: 10.1002/mds.28878

Szejko, N., Worbe, Y., Hartmann, A., Visser-Vandewalle, V., Ackermans, L., Ganos, C., Porta, M., Leentjens, A.F.G., Mehrkens, J.H., Huys, D., Baldermann, J.C., Kuhn, J., Karachi, C., Delorme, C., Foltynie, T., Cavanna, A.E., Cath, D, Müller-Vahl, K. (2022). European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part IV: deep brain stimulation. European Child & Adolescent Psychiatry, 31(3), 443-461. DOI: 10.1007/s00787-021-01881-9

Jergas, H., Petry-Schmelzer, J. N., Dembek, T. A., Dafsari, H. S., Visser-Vandewalle, V., Fink, G. R., Baldermann, J.C., Barbe, M. T. (2023). Brain morphometry associated with response to levodopa and deep brain stimulation in Parkinson disease. Neuromodulation: Technology at the Neural Interface, 26(2), 340-347. DOI: 10.1016/j.neurom.2022.01.013

Sildatke, E., Gruendler, T. O., Ullsperger, M., Dembek, T. A., Baldermann, J. C., Kohl, S., Visser-Vandewalle, V., Huys, D., Kuhn, J.,  Schüller, T. (2022). Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive–Compulsive Disorder. Neuromodulation: Technology at the Neural Interface, 25(2), 245-252. DOI: 10.1111/ner.13493

Tödt, I., Al‐Fatly, B., Granert, O., Kühn, A. A., Krack, P., Rau, J., Timmermann, L., Schnitzler, A., Paschen, S., Helmers, A.K., Hartmann, A., Bardinet, E., Schuepbach, M., Barbe, M.T., Dembek, T.A., Fraix, V., Kübler, D., Brefel-Courbon, C., Gharabaghi, A., Wojtecki, L., Pinsker, M.O., Thobois, S., Damier, P., Witjas, T., Houeto, J.L., Schade-Brittinger, C., Vidailhet, M., Horn, A., Deuschl, G. (2022). The contribution of subthalamic nucleus deep brain stimulation to the improvement in motor functions and quality of life. Movement disorders, 37(2), 291-301. DOI: 10.1002/mds.28952

Ophey, A., Wenzel, J., Paul, R., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., Kalbe, E., Kambeitz-Ilankovic, L. (2022). Cognitive Performance and Learning Parameters Predict Response to Working Memory Training in Parkinson’s Disease. Journal of Parkinson's Disease, 1-13. DOI: 10.3233/JPD-223448

Petry-Schmelzer, J. N., Schwarz, L. M., Jergas, H., Reker, P., Steffen, J. K., Dafsari, H. S., Baldermann, J.C., Fink, G.R., Visser-Vandewalle, V., Dembek, T. A., Barbe, M. T. (2022). A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson’s Disease. Journal of Parkinson's Disease, 1-9. DOI: 10.3233/JPD-213119.

Strelow, J. N., Baldermann, J. C., Dembek, T. A., Jergas, H., Petry-Schmelzer, J. N., Schott, F., Dafsari, H.S., Moll, C.K.E., Hamel, W., Gulberti, A., Visser-Vandewalle, V., Fink, G.R., Pötter-Nerger, M., Barbe, M. T. (2022). Structural connectivity of subthalamic nucleus stimulation for improving freezing of gait. Journal of Parkinson's Disease, (Preprint), 1-17. DOI: 10.3233/JPD-212997

Zapf, A. C., Folkerts, A. K., Kahler, L., Schnitzler, A., Reker, P., Barbe, M. T., Florin, E., Kalbe, E. (2022). No Higher Risk-Seeking Tendencies or Altered Self-Estimation in a Social Decision-Making Task in Patients with Parkinson’s Disease. Journal of Parkinson's Disease, 1-13. DOI: 10.3233/JPD-212960

Jacobsen, M., Rottmann, P., Dembek, T. A., Gerke, A. L., Gholamipoor, R., Blum, C., Hartmann, N.U., Verket, M., Kaivers, J., Jäger, P., Baermann, B.N., Heinemann, L., Marx, N., Müller-Wieland, D., Kollmann, M., Seyfarth, M., Kobbe, G. (2022). Feasibility of wearable-based remote monitoring in patients during intensive treatment for aggressive hematologic malignancies. JCO Clinical Cancer Informatics, 6, e2100126. DOI: 10.1200/CCI.21.00126 JCO

Sauerbier, A., Bachon, P., Ambrosio, L., Loehrer, P. A., Rizos, A., Jost, S. T., Gronostay, A., Konitsioti, A., Barbe, M.T., Fink, G.R., Ashkan, K., Nimsky, C., Visser-Vandewalle, V., Chaudhuri, K.R., Timmermann, L., Martinez-Martin, P., Dafsari, H.S., Dafsari, H. S. (2022). The New Satisfaction with Life and Treatment Scale (SLTS-7) in Patients with Parkinson’s Disease. Journal of Parkinson's Disease, 12(1), 453-464. DOI: 10.3233/JPD-212823

Nowacki, A., Barlatey, S., Al‐Fatly, B., Dembek, T., Bot, M., Green, A. L., Kübler, D., Lachenmayer, M.L., Debove, I., Segura-Amil, A., Horn, A., Visser-Vandewalle, V., Schuurman, R., Barbe, M. T., Aziz, T.Z., Kühn, A.A., Nguyen, T.A.K., Pollo, C. (2022). Probabilistic mapping reveals optimal stimulation site in essential tremor. Annals of neurology, 91(5), 602-612. DOI: 10.1002/ana.26324

Weiss, D., Landoulsi, Z., May, P., Sharma, M., Schüpbach, M., You, H., Corvol, J.C., Paschen, S., Helmers, A.K., Barbe, M.T., Fink, G. R., Kühn, A.A., Courbon, C.B., Wojtecki, L., Damier, P., Fraix, V., Houeto, J.L., Regis, J., Sixel-Döring, F., Pinsker, M.O., Thobois, S., Gharabaghi, A., Stoker, V., Timmermann, L., Schnitzler, A., Krack, P., Vidailhet, M., Deuschl G, Krüger, R. (2022). Genetic stratification of motor and QoL outcomes in Parkinson's disease in the EARLYSTIM study. Parkinsonism & related disorders, 103, 169-174. DOI: 10.1016/j.parkreldis.2022.08.025

2021

Heiden, P., Hoevels, M., Bayram, D., Baldermann, J. C., Schüller, T., Huys, D., Visser-Vandewalle, V., Andrade, P. (2021). Connectivity patterns of deep brain stimulation targets in patients with Gilles de la Tourette syndrome. Brain Sciences, 11(1), 87. DOI: 10.3390/brainsci11010087

Petry‐Schmelzer, J. N., Jergas, H., Thies, T., Steffen, J. K., Reker, P., Dafsari, H. S., Mücke, D., Fink, G.R., Visser-Vandewalle, V., Dembek, T.A., Barbe, M. T. (2021). Network Fingerprint of Stimulation‐Induced Speech Impairment in Essential Tremor. Annals of neurology, 89(2), 315-326. DOI: 10.1002/ana.25958

Park, J., Reilaender, A., Petry-Schmelzer, J. N., Stöbe, P., Cordts, I., Harmuth, F., Rautenberg, M., Woerz, S.E., Demidov, G., Sturm, M., Ossowski, S., Schwaibold, E.M.C., Wunderlich, G., Paus, S., Saft, C., Haack, T. B. (2022). Transcript-specific loss-of-function variants in VPS16 are enriched in patients with dystonia. Neurology Genetics, 8(1). DOI: 10.1212/NXG.0000000000000644

Petry-Schmelzer, J. N., Dembek, T. A., Steffen, J. K., Jergas, H., Dafsari, H. S., Fink, G. R., Visser-Vandewalle, V., Barbe, M. T. (2022). Correction: Petry-Schmelzer et al. Selecting the Most Effective DBS Contact in Essential Tremor Patients Based on Individual Tractography. Brain Sci. 2020, 10, 1015. Brain Sciences, 12(1), 64. DOI: 10.3390/brainsci12010064

Sauerbier, A., Loehrer, P., Jost, S. T., Heil, S., Petry-Schmelzer, J. N., Herberg, J., Bachon, P., Aloui, S., Gronostay, A., Klingelhoefer, L., Baldermann, J.C., Huys, D., Nimsky, C., Barbe, M.T., Fink, G.R., Martinez-Martin, P., Ray Chaudhuri, K., Visser-Vandewalle, V., Timmermann, L., Weintraub, D., Dafsari, H. S. (2021). Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease. Journal of Neurology, Neurosurgery & Psychiatry, 92(12), 1313-1318. DOI: 10.1136/jnnp-2021-326131

Kuhn, J., Baldermann, J. C. (2021). Neuromodulation via Deep Brain Stimulation in Obsessive-Compulsive Disorder—Present and Perspectives. Biological Psychiatry, 90(10), 664-666. DOI: 10.1016/j.biopsych.2021.09.002

Baldermann, J. C., Schüller, T., Kohl, S., Voon, V., Li, N., Hollunder, B., Figee, M., Haber, S.N., Sheth, S.A., Mosley, P.E., Huys, D., Johnson, K.A., Butson, C., Ackermans, L., Bouwens van der Vlis, T., Leentjens, A.F.G., Barbe, M. T., Visser-Vandewalle, V., Kuhn, J., Horn, A. (2021). Connectomic deep brain stimulation for obsessive-compulsive disorder. Biological Psychiatry, 90(10), 678-688. DOI: 10.1016/j.biopsych.2021.07.010

Li, N., Hollunder, B., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Al-Fatly, B., Strange, B.A., Barcia, J.A., Zrinzo, L., Joyce, E.M., Chabardes, S., Visser-Vandewalle, V., Polosan, M., J, Kühn, A.A., Horn, A. (2021). A unified functional network target for deep brain stimulation in obsessive-compulsive disorder. Biological Psychiatry, 90(10), 701-713. DOI: 10.1016/j.biopsych.2021.04.006

Dembek, T. A., Hellerbach, A., Jergas, H., Eichner, M., Wirths, J., Dafsari, H. S., Barbe, M.T., Hunsche, S., Visser-Vandewalle, V., Treuer, H. (2021). DiODe v2: unambiguous and fully-automated detection of directional DBS lead orientation. Brain Sciences, 11(11), 1450. DOI: 10.3390/brainsci11111450

Wehmeyer, L., Schüller, T., Kiess, J., Heiden, P., Visser-Vandewalle, V., Baldermann, J. C., Andrade, P. (2021). Target-specific effects of deep brain stimulation for Tourette syndrome: a systematic review and meta-analysis. Frontiers in Neurology, 12, 769275. DOI: 10.3389/fneur.2021.769275

Baldermann, J. C., Kuhn, J., Schüller, T., Kohl, S., Andrade, P., Schleyken, S., Prinz-Langenohl, R., Hellmich, M., Barbe, M.T., Timmermann, L., Visser-Vandewalle, V., Huys, D. (2021). Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods. Brain Stimulation, 14(5), 1059-1067. DOI: 10.1016/j.brs.2021.07.003

Seger, A. D., Farrher, E., Doppler, C. E., Gogishvili, A., Worthoff, W. A., Filss, C. P., Barbe, M.T., Holtbernd, F., Shah, N.J., Fink, G.R., Sommerauer, M. (2021). Putaminal y‐Aminobutyric Acid Modulates Motor Response to Dopaminergic Therapy in Parkinson's Disease. Movement Disorders, 36(9), 2187-2192. DOI: 10.1002/mds.28674

Jergas, H., Grindegård, L., Schultze, T., Thanarajah, S. E., Kalbe, E., Van Eimeren, T., Dafsari, H.S., Dembek, T.A., Visser-Vandewalle, V., Fink, G.R., Timmermann, L., Schilbach, L., Barbe, M. T. (2021). The impact of subthalamic deep brain stimulation on belief revision and social validation. Parkinsonism & related disorders, 89, 84-86. DOI: 10.1016/j.parkreldis.2021.06.020

Petry‐Schmelzer, J. N., Keller, N., Karakaya, M., Wirth, B., Fink, G. R., Wunderlich, G. (2021). VPS13D: one family, same mutations, two phenotypes. Movement disorders clinical practice, 8(5), 803. DOI: 10.1002/mdc3.13232

Schüller, C. B., Wagner, B. J., Schüller, T., Baldermann, J. C., Huys, D., Kerner auch Koerner, J., Niessen, E., Münchau, A., Brandt, V., Peters, J., Kuhn, J. (2021). Temporal discounting in adolescents and adults with Tourette syndrome. PLoS One, 16(6), e0253620. DOI: 10.1371/journal.pone.0253620

Jost, S. T., Visser-Vandewalle, V., Rizos, A., Loehrer, P. A., Silverdale, M., Evans, J.,  Samuel, M., Petry-Schmelzer, J.N., Sauerbier, A., Gronostay, A., Barbe, M.T., Fink, G.R., Ashkan, K., Antonini, A., Martinez-Martin, P., Chaudhuri, K.R., Timmermann, L., Dafsari, H. S. (2021). Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease. npj Parkinson's Disease, 7(1), 48. DOI: 10.1038/s41531-021-00174-x

Thies, T., Mücke, D., Dano, R., Barbe, M. T. (2021). Levodopa-based changes on vocalic speech movements during prosodic prominence marking. Brain Sciences, 11(5), 594. DOI: 10.3390/brainsci11050594

Liao, T. C., Jergas, H., Tibrewala, R., Bahroos, E., Link, T. M., Majumdar, S., Souza, R.B., Pedoia, V. (2021). Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features. Journal of Orthopaedic Research®, 39(3), 506-515. DOI: 10.1002/jor.24836

Ophey, A., Rehberg, S., Giehl, K., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2021). Predicting working memory training responsiveness in Parkinson’s disease: both “System Hardware” and room for improvement are needed. Neurorehabilitation and Neural Repair, 35(2), 117-130. DOI: 0.1177/1545968320981956

Sprute, R., Jergas, H., Ölmez, A., Alawbathani, S., Karasoy, H., Dafsari, H. S., Nürnberg, P., Muntoni, F., Topaloglu, H., Uyanik, G., Cirak, S. (2021). Genotype–phenotype correlation in seven motor neuron disease families with novel ALS2 mutations. American Journal of Medical Genetics Part A, 185(2), 344-354. DOI: 10.1002/ajmg.a.61951

Schüller, T., Gruendler, T. O., Smith, E. E., Baldermann, J. C., Kohl, S., Fischer, A. G., Visser-Vandewalle, V., Ullsperger, M., Kuhn, J.,Huys, D. (2021). Performance monitoring in obsessive–compulsive disorder: Insights from internal capsule/nucleus accumbens deep brain stimulation. NeuroImage: Clinical, 31, 102746. DOI: 10.1016/j.nicl.2021.102746

Schedlich-Teufer, C., Jost, S. T., Krack, P., Witt, K., Weintraub, D., Baldermann, J. C., Sommerauer, M., Amstutz, D., van Eimeren, T., Dafsari, H.S., Kalbe, E., Visser-Vandewalle, V., Fink, G.R., Kessler, J., Barbe, M. T. (2021). Assessment of Affective-Behavioral States in Parkinson’s Disease Patients: Towards a New Screening Tool. Journal of Parkinson's disease, 11(3), 1417-1430. DOI: 10.3233/JPD-202375

Kramme, J., Dembek, T. A., Treuer, H., Dafsari, H. S., Barbe, M. T., Wirths, J., Visser-Vandewalle, V. (2021). Potentials and limitations of directional deep brain stimulation: a simulation approach. Stereotactic and Functional Neurosurgery, 99(1), 65-74. DOI: 10.1159/000509781

Jost, S. T., Ray Chaudhuri, K., Ashkan, K., Loehrer, P. A., Silverdale, M., Rizos, A., Evans J, Petry-Schmelzer, J.N,. Barbe, M.T., Sauerbier, A., Fink, G.R., Visser-Vandewalle, V., Antonini, A., Martinez-Martin, P., Timmermann L, Dafsari, H. S. (2021). Subthalamic stimulation improves quality of sleep in Parkinson disease: a 36-month controlled study. Journal of Parkinson's disease, 11(1), 323-335. DOI: 10.3233/JPD-202278

Dembek, T. A., Asendorf, A. L., Wirths, J., Barbe, M. T., Visser-Vandewalle, V., Treuer, H. (2021). Temporal stability of lead orientation in directional deep brain stimulation. Stereotactic and Functional Neurosurgery, 99(2), 167-170. DOI: 10.1159/000510883

2020

Petry-Schmelzer, J. N., Dembek, T. A., Steffen, J. K., Jergas, H., Dafsari, H. S., Fink, G. R., Visser-Vandewalle, V., Barbe, M. T. (2020). Selecting the most effective DBS contact in essential tremor patients based on individual tractography. Brain Sciences, 10(12), 1015. DOI: 10.3390/brainsci10121015

Steffen, J. K., Jergas, H., Petry-Schmelzer, J. N., Dembek, T. A., Thies, T., Jost, S.T., Dafsari, H.S., Kessler, J., Wirths, J., Fink, G.R., Visser-Vandewalle, V., Barbe, M. T. (2020). Thalamic deep brain stimulation in essential tremor plus is as effective as in essential tremor. Brain Sciences, 10(12), 970. DOI: 10.3390/brainsci10120970

Brendel, M., Barthel, H., van Eimeren, T., Marek, K., Beyer, L., Song, M., …, Barbe, M.T. .., Sabri, O. (2020). Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy. JAMA neurology, 77(11), 1408-1419. DOI: 10.1001/jamaneurol.2020.2526

Sprute, R., Jergas, H., Ölmez, A., Alawbathani, S., Karasoy, H., Dafsari, H. S., Becker, K., Nürnberg, P., Muntoni, F., Topaloglu, H., Uyanik, G., Cirak, S. (2021). Genotype–phenotype correlation in seven motor neuron disease families with novel ALS2 mutations. American Journal of Medical Genetics Part A, 185(2), 344-354. DOI: 10.1002/ajmg.a.61951

Kramme, J., Dembek, T. A., Treuer, H., Dafsari, H. S., Barbe, M. T., Wirths, J., & Visser-Vandewalle, V. (2021). Potentials and limitations of directional deep brain stimulation: a simulation approach. Stereotactic and Functional Neurosurgery, 99(1), 65-74. DOI: 10.1159/000509781

Jost, S. T., Ray Chaudhuri, K., Ashkan, K., Loehrer, P. A., Silverdale, M., Rizos, A., Evans, J., Petry-Schmelzer, J. N., Barbe, M.T., Sauerbier, A., Fink, G.R., Visser-Vandewalle, V., Antonini, A., Martinez-Martin, P., Timmermann, L., Dafsari, H.S. (2021). Subthalamic stimulation improves quality of sleep in Parkinson disease: a 36-month controlled study. Journal of Parkinson's disease, 11(1), 323-335. DOI: 10.3233/JPD-202278

Dembek, T. A., Asendorf, A. L., Wirths, J., Barbe, M. T., Visser-Vandewalle, V., Treuer, H. (2021). Temporal stability of lead orientation in directional deep brain stimulation. Stereotactic and Functional Neurosurgery, 99(2), 167-170. DOI: 10.1159/000510883

Dafsari, H. S., dos Santos Ghilardi, M. G., Visser-Vandewalle, V., Rizos, A., Ashkan, K., Silverdale, M., Evans, J., Martinez, R.C.R., Cury, R.G., Jost, S.T., Barbe, M.T., Fink, G.R., Antonini, A., Ray-Chaudhuri, K., Martinez-Martin, P., Fonoff, E.T., Timmermann, L. (2020). Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease. Brain stimulation, 13(6), 1697-1705. DOI: 10.1016/j.brs.2020.09.019

Jacobsen, M., Dembek, T. A., Ziakos, A. P., Gholamipoor, R., Kobbe, G., Kollmann, M., Blum, C., Müller-Wieland, D., Napp, A., Heinemann, L., Deubner, N., Marx, N., Isenmann, S., Seyfarth, M. (2020). Reliable detection of atrial fibrillation with a medical wearable during inpatient conditions. Sensors, 20(19), 5517. DOI: 10.3390/s20195517

Johnson, K. A., Duffley, G., Anderson, D. N., Ostrem, J. L., Welter, M. L., Baldermann, J. C.,  Kuhn, J., Huys, D., Visser-Vandewalle, V., Foltynie, T., Zrinzo, L., Hariz, M., Leentjens, A.F.G., Mogilner, A.Y., Pourfar, M.H., Almeida, L., Gunduz, A., Foote, K.D., Okun, M.S., Butson, C. R. (2020). Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome. Brain, 143(8), 2607-2623. DOI: 10.1093/brain/awaa188

Smith, E. E., Schüller, T., Huys, D., Baldermann, J. C., Andrade, P., Allen, J. J., Visser-Vandewalle, V., Ullsperger, M., Gruendler, T.O.J., Kuhn, J. (2020). A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes. Neuroimage, 220, 117138. DOI: 10.1016/j.neuroimage.2020.117138

Li, N., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Elias, G. J., Boutet, A., Lozano, A.M., Al-Fatly, B., Strange, B., Barcia, J.A., Zrinzo, L., Joyce, E., Chabardes, S., Visser-Vandewalle, V., Polosan, M., Kuhn, J., Kühn, A.A., Horn, A. (2020). A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nature communications, 11(1), 3364. DOI: 10.1038/s41467-020-16734-3

Kuhn, J., Baldermann, J. C. (2020). Elucidating neural network changes induced by deep brain stimulation for OCD. Brain, 143(5), 1293-1296. DOI: 10.1093/brain/awaa108

Andrade, P., Heiden, P., Hoevels, M., Schlamann, M., Baldermann, J. C., Huys, D., Visser-Vandewalle, V. (2020). Modulation of fibers to motor cortex during thalamic DBS in Tourette patients correlates with tic reduction. Brain Sciences, 10(5), 302. DOI: 10.3390/brainsci10050302

Jost, S. T., Sauerbier, A., Visser-Vandewalle, V., Ashkan, K., Silverdale, M., Evans, J., Loehrer, P.A., Rizos, A., Petry-Schmelzer, J.N., Reker, P., Fink, G.R., Franklin, J., Samuel, M., Schnitzler, A., Barbe, M.T., Antonini, A., Martinez-Martin, P., Timmermann, L., Ray-Chaudhuri, K., Dafsari, H. S. (2020). A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up. Journal of Neurology, Neurosurgery & Psychiatry, 91(7), 687-694. DOI: https://jnnp.bmj.com/content/91/7/687

Beyer, L., Nitschmann, A., Barthel, H., van Eimeren, T., Unterrainer, M., Sauerbeck, J., Marek, K., Song, M., Palleis, C., Respondek, G., Hammes, J., Barbe, M.T., Onur, Ö., Jessen, F., Saur, D., Schroeter, M.L., Rumpf, J.J., Rullmann, M., Schildan, A., Patt, M., Neumaier, B., Barret, O., Madonia, J., Russell, D.S., Stephens, A.W., Roeber, S., Herms, J., Bötzel, K., Levin, J., Classen, J., Höglinger, G.U., Bartenstein, P., Villemagne, V., Drzezga, A., Seibyl, J., Sabri, O., Brendel, M. (2020). Early-phase [18 F] PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. European journal of nuclear medicine and molecular imaging, 47, 2911-2922. DOI: 10.1016/j.brainresbull.2016.08.018.

Irmen, F., Horn, A., Mosley, P., Perry, A., Petry‐Schmelzer, J. N., Dafsari, H. S., Barbe, M., T. Visser-Vandewalle, V., Schneider, G.H., Li, N., Kübler, D., Wenzel, G., Kühn, A. A. (2020). Left prefrontal connectivity links subthalamic stimulation with depressive symptoms. Annals of Neurology, 87(6), 962-975. DOI: 10.1002/ana.25734

Dafsari, H. S., Ray-Chaudhuri, K., Ashkan, K., Sachse, L., Mahlstedt, P., Silverdale, M., Rizos, A., Strack, M., Jost, S.T., Reker, P., Samuel, M., Visser-Vandewalle, V., Evans, J., Antonini, A., Martinez-Martin, P., Timmermann, L. (2020). Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease. Journal of neurology, 267, 1830-1841. DOI: 10.1007/s00415-020-09743-1

Schüller, T., Fischer, A. G., Gruendler, T. O., Baldermann, J. C., Huys, D., Ullsperger, M., Kuhn, J. (2020). Decreased transfer of value to action in Tourette syndrome. Cortex, 126, 39-48. DOI: 10.1016/j.cortex.2019.12.027

Smith, E. E., Schüller, T., Huys, D., Baldermann, J. C., Ullsperger, M., Allen, J. J., Visser-Vandewalle, V., Kuhn, J., Gruendler, T. O. (2020). Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 13(1), 259-261. DOI: 10.1016/j.brs.2019.09.008

Barbe, M.T., Tonder, L., Krack, P., Debû, B., Schüpbach, M., Paschen, S., Dembek, T.A., Kühn, A.A., Fraix, V., Brefel‐Courbon, C., Wojtecki, L., Maltête, D., Damier, P., Sixel‐Döring, F., Weiss, D., Pinsker, M., Witjas, T., Thobois, S., Schade‐Brittinger, C., Rau, J., Houeto, J.‐L., Hartmann, A., Timmermann, L., Schnitzler, A., Stoker, V., Vidailhet, M., Deuschl, G. (2020). Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease With Early Motor Complications. Mov Disord. 35: 82-90. DOI:10.1002/mds.27892

Becker, J., Thies, T., Petry-Schmelzer, J.N., Dembek, T.A., Reker, P., Mücke, D., Grice, M., Visser-Vandewalle, V., Fink, G.R., Barbe, M.T. (2020). The effects of thalamic and posterior subthalamic deep brain stimulation on speech in patients with essential tremor – A prospective, randomized, doubleblind crossover study. Brain and Language. Vol. 202. 104724. DOI: https://doi.org/10.1016/j.bandl.2019.104724.

Dembek, T. A., Petry-Schmelzer, J. N., Reker, P., Wirths, J., Hamacher, S., Steffen, J., Dafsari, H. S., Hövels, M., Fink, G. R., Visser-Vandewalle, V., Barbe, M. T. (2020). PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract. NeuroImage. Clinical, 26, 102235. Advance online publication. DOI: https://doi.org/10.1016/j.nicl.2020.102235

Jacobsen, M., Dembek, T. A., Kobbe, G., Gaidzik, P. W., Heinemann, L. (2020). Noninvasive Continuous Monitoring of Vital Signs With Wearables: Fit for Medical Use? Journal of Diabetes Science and Technology. DOI: https://doi.org/10.1177/1932296820904947

Giehl, K., Ophey, A., Reker, P., Rehberg, S., Hammes, J., Barbe, M. T., Zokaei, N., Eggers, C., Husain, M., Kalbe, E., van Eimeren, T. (2020). Effects of Home-Based Working Memory Training on Visuo-Spatial Working Memory in Parkinson's Disease: A Randomized Controlled Trial. Journal of central nervous system disease, 12, 1179573519899469. DOI: https://doi.org/10.1177/1179573519899469

Steffen, J.K., Reker, P., Mennicken, F.K., Dembek, T.A., Dafsari, H.S., Fink, G.R., Visser‐Vandewalle, V., Barbe, M.T. (2020). Bipolar Directional Deep Brain Stimulation in Essential and Parkinsonian Tremor. Neuromodulation: Technology at the Neural Interface. DOI:10.1111/ner.13109

Thies, T., Mücke, D., Lowit, A., Kalbe, E., Steffen, J., Barbe, M.T. (2020). Prominence marking in parkinsonian speech and its correlation with motor performance and cognitive abilities. Neuropsychologia. Volume 137. 107306 DOI: https://doi.org/10.1016/j.neuropsychologia.2019.107306.

2019

Baldermann, J.C., Hahn, L., Dembek, T.A., Kohl, S., Kuhn, J., Visser-Vandewalle, V., Horn, A., Huys, D. (2019). Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus. Brain Sci. 9, 264. DOI: https://doi.org/10.3390/brainsci9100264

Barbe, A.G., Ludwar, L., Scharfenberg, I., Hellmich, M., Dano, R., Barbe, M.T., Noack, M.J. (2019). Circadian rhythms and influencing factors of xerostomia among Parkinson’s disease patients. Oral Dis. 25: 282– 289. DOI: https://doi.org/10.1111/odi.12942

Dafsari, H.S., Martinez‐Martin, P., Rizos, A., Trost, M., dos Santos Ghilardi, M.G., Reddy, P., Sauerbier, A., Petry‐Schmelzer, J.N., Kramberger, M., Borgemeester, R.W.K., Barbe, M.T., Ashkan, K., Silverdale, M., Evans, J., Odin, P., Fonoff, E.T., Fink, G.R., Henriksen, T., Ebersbach, G., Pirtošek, Z., Visser‐Vandewalle, V., Antonini, A., Timmermann, L., Ray Chaudhuri, K. and (2019), EuroInf 2: Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease. Mov Disord., 34: 353-365. DOI: 10.1002/mds.27626

Dafsari, H.S., Ray‐Chaudhuri, K., Mahlstedt, P., Sachse, L., Steffen, J.K., Petry‐Schmelzer, J.N., Dembek, T.A., Reker, P., Barbe, M.T., Visser‐Vandewalle, V., Fink, G.R. and Timmermann, L. (2019). Beneficial effects of bilateral subthalamic stimulation on alexithymia in Parkinson's disease. Eur J Neurol, 26: 222-e17. DOI:10.1111/ene.13773

Dembek, T.A., Hoevels, M., Hellerbach, A., Horn, A., Petry-Schmelzer, J.N., Borggrefe, J., Wirths, J., Dafsari, H.S., Barbe, M.T., Visser-Vandewalle, V., Treuer, H. (2019). Directional DBS leads show large deviations from their intended implantation orientation. Parkinsonism & Related Disorders. Volume 67. p.:117-121. DOI: https://doi.org/10.1016/j.parkreldis.2019.08.017.

Dembek, T.A., Roediger, J., Horn, A., Reker, P., Oehrn, C., Dafsari, H.S., Li, N., Kühn, A.A., Fink, G.R., Visser‐Vandewalle, V., Barbe, M.T., Timmermann, L. (2019). Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease. Ann Neurol, 86: 527-538. DOI:10.1002/ana.25567

Edwin Thanarajah S., Prüss, H., Warnke C., Barbe M.T., Schroeter, M., Fink, G.R., Onur O.A. (2019). Atypical Autoimmune Encephalitis With Neuropil Antibodies Against a Yet Unknown Epitope. Frontiers in Neurology. Vol. 10. P. 175. DOI:10.3389/fneur.2019.00175 

Hermes, A., Mücke, D., Thies, T., Barbe, M.T. (2019). Coordination patterns in Essential Tremor patients with Deep Brain Stimulation: Syllables with low and high complexity. Laboratory Phonology: Journal of the Association for Laboratory Phonology, 10(1), 6. DOI: http://doi.org/10.5334/labphon.141            

Horn, A., Li, N., Dembek, T.A., Kappel, A., Boulay, C., Ewert, S., Tietze, A., Husch, A., Perera, T., Neumann, W.J., Reisert, M., Si, H., Oostenveld, R., Rorden, C., Yeh, F.C., Fang, Q., Herrington, T.M., Vorwerk, J., Kühn, A.A. (2019). Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging. NeuroImage. Vol. 184. p. 293-316. DOI: https://doi.org/10.1016/j.neuroimage.2018.08.068.

Knudsen, K., Krack, P., Tonder, L., Houeto, J.-L., Rau, J., Schade-Brittinger, C., Hartmann, A., Hälbig, T.D., Paschen, S., Barbe, M.T., Kühn, A., Fraix, V., Brefel-Courbon, C., Vesper, J., Maltête, D., Sixel-Döring, F., Weiss, D., Witjas, T., Thobois, S., Agid, Y., Schnitzler, A., Schuepbach, W.M.M., Timmermann, L., Damier, P., Vidailhet, M., Deuschl, G. (2019). Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial. Parkinsonism & Related Disorders.Vol. 65.p. 217-223. DOI: https://doi.org/10.1016/j.parkreldis.2019.05.023

Nettersheim, F.S., Loehrer, P.A., Weber, I., Jung, F., Dembek, T.A., Pelzer, E.A., Dafsari, H.S., Huber, C.A., Tittgemeyer, M., Timmermann, L. (2019). Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. NeuroImage. Vol. 190. p. 118-132. DOI: https://doi.org/10.1016/j.neuroimage.2018.04.030

Petry-Schmelzer, J.N., Krause, M., Dembek, T.A., Horn, A., Evans, J., Ashkan, K., Rizos, A., Silverdale, M., Schumacher, W., Sack, C., Loehrer, P.A., Fink, G.R., Fonoff, E.T., Martinez-Martin, P., Antonini, A., Barbe, M.T., Visser-Vandewalle, V., Ray-Chaudhuri, K., Timmermann, L., Dafsari, H.S., EUROPAR and the IPMDS Non-Motor PD Study Group. (2019). Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease. Brain, Volume 142, Issue 11. P. 3592–3604. DOI: https://doi.org/10.1093/brain/awz285

Petry‐Schmelzer, J.N., Reker, P., Pochmann, J., Visser‐Vandewalle, V., Dembek, T.A., Barbe, M.T. (2019). Daily Alternation of DBS Settings Does Not Prevent Habituation of Tremor Suppression in Essential Tremor Patients. Mov Disord Clin Pract, 6: 417-418. DOI:10.1002/mdc3.12777

Reker, P., Thies, T., Josten, A.F., Steffen, J.K., Dafsari, H.S., Visser-Vandewalle, V., Barbe, M.T. (2019). Evaluation of a German version of the Bain and Findley Tremor ADL scale. Parkinsonism & Related Disorders. Vol. 68. P. 46-48. DOI:   https://doi.org/10.1016/j.parkreldis.2019.09.024

Schuepbach,W.M., Tonder, L., Schnitzler, A., Krack, P., Rau, J.,Hartmann, A., Hälbig, T.D., Pineau, F., Falk, A., Paschen, L., Paschen, S., Volkmann, J., Dafsari, H.S., Barbe, M.T., Fink, G.R., Kühn, A., Kupsch, A., Schneider, G.H., Seigneuret, E., Fraix, V., Kistner, A., Chaynes, P., Ory-Magne, F., Brefel-Courbon, C., Vesper, J., Wojtecki, L., Derrey, S., Maltête, D., Damier, P., Derkinderen, P., Sixel-Döring, F., Trenkwalder, C., Gharabaghi, A., Wächter, T., Weiss, D., Pinsker, M.O., Regis, J.M., Witjas, T., Thobois, S., Mertens, P., Knudsen, K., Schade-Brittinger, C., Houeto, J.L., Agid, Y., Vidailhet, M., Timmermann, L., Deuschl, G. for the EARLYSTIM study group. (2019). Quality of life predicts outcome of deep brain stimulation in early Parkinson disease. Neurology, 92 (10) e1109-e1120. DOI: 10.1212/WNL.0000000000007037

Sidiropoulos, C. (2019). Reader response: DBS of the PSA and the VIM in essential tremor: A randomize, double-blind, crossover trial. Neurology, 92 (20) 975; DOI: 10.1212/WNL.0000000000007522

Sommerauer, M., Galldiks, N., Barbe, M.T., Stoffels, G., Willuweit, A., Coenen, H.H., Schroeter, M., Timmermann, L., Fink, G.R., Langen, K.J. (2019). Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism. Nuclear Medicine Communications. Vol. 40. P. 383 – 387. DOI: 10.1097/MNM.0000000000000982

Sukiban, J., Voges, N., Dembek, T.A., Pauli, R., Visser-Vandewalle, V., Denker, M., Weber, I., Timmermann, L., Grün, S. (2019). Evaluation of Spike Sorting Algorithms: Application to Human Subthalamic Nucleus Recordings and Simulations. Neuroscience. Vol. 414. P. 168-185. DOI: https://doi.org/10.1016/j.neuroscience.2019.07.005.

2018

Allert, N., Cheeran, B., Deuschl, G., Barbe, M. T., Csoti, I., Ebke, M., Glaser, M., Kangh, J.-S., Kelm, S., Krack, P., Kroth, J., Jobst, U., Leisse, M., Oliviero, A., Nolte, P. N., Quick-Weller, J., Strothjohann, M., Tamás, G., Werner, M., Muthuraman, M., Volkmann, J., Fasano, A., Groppa, S. (2018). Postoperative rehabilitation after deep brain stimulation surgery for movement disorders. Clinical Neurophysiology, 129(3), 592-601. DOI: https://doi.org/10.1016/j.clinph.2017.12.035

Allert, N., Lindlau, A., Quindt, R., Reker, P., Timmermann, L., Barbe, M. T. (2018). Unstable impedance of a single electrode contact resulting in loss of DBS therapy—a case report. Acta neurochirurgica, 160(12), 2485-2488. DOI: doi.org/10.1007/s00701-018-3658-x

Barbe, A. G., Ludwar, L., Scharfenberg, I., Hellmich, M., Dano, R., Barbe, M. T., Noack, M. J. (2019). Circadian rhythms and influencing factors of xerostomia among Parkinson’s disease patients. Oral diseases, 25(1), 282-289. DOI: https://doi.org/10.1111/odi.12942

Barbe, A. G., Noack, M. J., Barbe, M. T., & Nitschke, I. (2018). Contusion of the cervical spinal cord following dental treatment of a patient at risk to stroke: A case report. Gerodontology, 35(1), 63-65. DOI: https://doi.org/10.1111/ger.12316

Barbe, M. T., Barthel, C., Chen, L., Van Dyck, N., Brücke, T., Seijo, F., Suarez San Martin, E., Haegelen, C., Verin, M., Amarell, M., Gill, S., Whone, A., Porta, M., Servello, D., Fink, G.R., Alesch, F., Bloem, B.R., Timmermann, L. (2018). Subthalamic nucleus deep brain stimulation reduces freezing of gait subtypes and patterns in Parkinson's disease. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 11(6), 1404-1406. DOI: https://doi.org/10.1016/j.brs.2018.08.016

Barbe, M. T., Reker, P., Hamacher, S., Franklin, J., Kraus, D., Dembek, T. A., Becker, J., Steffen, J.K., Allert, N., Wirths, J., Dafsari, H.S., Voges, J., Fink, G.R., Visser-Vandewalle, V., & Timmermann, L. (2018). DBS of the PSA and the VIM in essential tremor: A randomized, double-blind, crossover trial. Neurology, 91(6), e543-e550. DOI: doi.org/10.1212/WNL.0000000000005956

Dafsari, H. S., Petry-Schmelzer, J. N., Ray-Chaudhuri, K., Ashkan, K., Weis, L., Dembek, T. A., Samuel, M., Rizos, A., Silverdale, M., Barbe, M.T., Fink, G.R., Evans, J., Martinez-Marting, P., Antonini, A., Visser-Vandewalle, V., Timmermann, L. (2018). Non-motor outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts. Brain stimulation, 11(4), 904-912. DOI: https://doi.org/10.1016/j.brs.2018.03.009

Dafsari, H. S., Reker, P., Silverdale, M., Reddy, P., Pilleri, M., Martinez‐Martin, P., Rizos, A., Perrier, E., Weiß, L., Ashkan, K.,  Samuel, Evans, J., Visser‐Vandewalle, V., Antonini, A., Ray‐Chaudhuri, K., Timmermann, L. (2018). Subthalamic stimulation improves quality of life of patients aged 61 years or older with short duration of Parkinson's disease. Neuromodulation: Technology at the Neural Interface, 21(6), 532-540. DOI: https://doi.org/10.1111/ner.12740

Dafsari, H. S., Reker, P., Stalinski, L., Silverdale, M., Rizos, A., Ashkan, K., Barbe, M.T., Fink, G.R., Evans, J., Steffen, J., Samuel, M., Dembek, T.A., Visser-Vandewalle, V., Antonini, A., Ray‐Chaudhuri, K., Martinez‐Martin, P.,  Timmermann, L. (2018). Quality of life outcome after subthalamic stimulation in Parkinson's disease depends on age. Movement Disorders, 33(1), 99-107. DOI: https://doi.org/10.1002/mds.27222

Dafsari, H.S., Silverdale, M., Strack, M., Rizos, A., Ashkan, K., Mahlstedt, P., Sachse, L., Steffen, J., Dembek, T.A., Visser‐Vandewalle, V., Evans, J., Antonini, A., Martinez‐Martin, P., Ray‐Chaudhuri, K., Timmermann, L. (2018). Nonmotor symptoms evolution during 24 months of bilateral subthalamic stimulation in Parkinson's disease. Mov Disord., 33: 421-430. doi:10.1002/mds.27283

Dafsari, H. S., Weiß, L., Silverdale, M., Rizos, A., Reddy, P., Ashkan, K., Evans, J., Reker, P., Petry-Schmelzer, J.N., Samuel, M., Visser-Vandewalle, V., Antonini, A., Martinez-Martin, P., Ray-Chaudhuri, K., & Timmermann, L. (2018). Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease. Brain stimulation, 11(4), 867-874. DOI: https://doi.org/10.1016/j.brs.2018.02.015

Eggers, C., Dano, R., Schill, J., Fink, G. R., Hellmich, M., Timmermann, L., & CPN study group. (2018). Patient-centered integrated healthcare improves quality of life in Parkinson’s disease patients: a randomized controlled trial. Journal of neurology, 265(4), 764-773. DOI: https://doi.org/10.1007/s00415-018-8761-7

Eggers, C., Dano, R., Schill, J., Fink, G. R., Timmermann, L., Voltz, R., Golla, H., & Lorenzl, S. (2018). Access to end-of life Parkinson's disease patients through Patient-centered integrated healthcare. Frontiers in neurology, 9, 627. DOI: https://doi.org/10.3389/fneur.2018.00627

Hellerbach, A., Dembek, T. A., Hoevels, M., Holz, J. A., Gierich, A., Luyken, K., Barbe, M.T., Wirths, J., Visser-Vandewalle, V., & Treuer, H. (2018). DiODe: directional orientation detection of segmented deep brain stimulation leads: a sequential algorithm based on CT imaging. Stereotactic and functional neurosurgery, 96(5), 335-341. DOI: https://doi.org/10.1159/000494738

Lhommée, E., Wojtecki, L., Czernecki, V., Witt, K., Maier, F., Tonder, L., Timmermann, L., Hälbig, T.D., Pineau, F., Durif, F., Witjas, T., Pinsker, M., Mehdorn, M., Sixel-Döring, F., Kupsch, A., Krüger, R., Elben, S., Chabardès, S., Thobois, S., Brefel-Courbon, C., Ory-Magne, F., Regis, J.-M., Maltête, D.,Sauvaget, A., Rau, J., Schnitzler, A., Schüpbach, M., Schade-Brittinger, C., Deuschl, G., Houeto, J.-L., & Krack, P. (2018). Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial. The Lancet Neurology, 17(3), 223-231. DOI: https://doi.org/10.1016/S1474-4422(18)30035-8

Dafsari, H.S., Silverdale, M., Strack, M., Rizos, A., Ashkan, K., Mahlstedt, P., Sachse, L., Steffen, J., Dembek, T.A., Visser‐Vandewalle, V., Evans, J., Antonini, A., Martinez‐Martin, P., Ray‐Chaudhuri, K., Timmermann, L.  (2018), Nonmotor symptoms evolution during 24 months of bilateral subthalamic stimulation in Parkinson's disease. Mov Disord., 33: 421-430. DOI: 10.1002/mds.27283

Mücke, D., Hermes, A., Roettger, T.B., Becker, J., Niemann, H., Dembek, T.A., Timmermann, L., Visser-Vandewalle, V., Fink, G. R., Grice, M., Barbe, M.T. (2018). The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study. PLOS One, 13(1). DOI: https://doi.org/10.1371/journal.pone.0191359

Nettersheim, F. S., Loehrer, P. A., Weber, I., Jung, F., Dembek, T. A., Pelzer, E. A., Dafsari, H.S., Huber, C.A., Tittgemeyer, M.,Timmermann, L. (2019). Dopamine substitution alters effective connectivity of cortical prefrontal, premotor, and motor regions during complex bimanual finger movements in Parkinson's disease. NeuroImage, 190, 118-132. DOI: https://doi.org/10.1016/j.neuroimage.2018.04.030

Ophey, A., Eggers, C., Dano, R., Timmermann, L., & Kalbe, E. (2018). Health-related quality of life subdomains in patients with Parkinson’s Disease: The role of gender. Parkinson’s Disease, 2018. DOI: https://doi.org/10.1155/2018/6532320

Pauls, K. A. M., Bröckelmann, P. J., Hammesfahr, S., Becker, J., Hellerbach, A., Visser-Vandewalle, V., Dembek, T.A., Meister, G. & Timmermann, L. (2018). Dysarthria in pallidal deep brain stimulation in dystonia depends on the posterior location of active electrode contacts: a pilot study. Parkinsonism & related disorders, 47, 71-75. DOI: https://doi.org/10.1016/j.parkreldis.2017.11.002

Rosen, J., Blau, T., Grau, S. J., Barbe, M. T., Fink, G. R., & Galldiks, N. (2018). Extracranial metastases of a cerebral glioblastoma: a case report and review of the literature. Case reports in oncology, 11(2), 591-600. DOI: https://doi.org/10.1159/000492111

Sommerauer, M., Hansen, A. K., Parbo, P., Fedorova, T. D., Knudsen, K., Frederiksen, Y., Nahimi, A., Barbe, M.T., Brooks, D.J., & Borghammer, P. (2018). Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients. Movement Disorders, 33(6), 1006-1010. DOI: https://doi.org/10.1002/mds.27411

Steigerwald, F., Timmermann, L., Kühn, A., Schnitzler, A., Reich, M. M., Kirsch, A. D., Barbe, M.T., Visser‐Vandewalle, V., Hübl, J., van Riesen, C., Groiss, S.J., Moldovan, A.-S., Lin, S., Carcieri, S., Manola, L., & Volkmann, J. (2018). Pulse duration settings in subthalamic stimulation for Parkinson's disease. Movement Disorders, 33(1), 165-169. DOI: https://doi.org/10.1002/mds.27238

2017

Allert, N., Barbe, M. T., Timmermann, L., & Coenen, V. A. (2017). Rapid battery depletion and loss of therapy due to a short circuit in bipolar DBS for essential tremor. Acta neurochirurgica, 159(5), 795-798. DOI: https://doi.org/10.1007/s00701-017-3090-7

Becker, J., Barbe, M. T., Hartinger, M., Dembek, T. A., Pochmann, J., Wirths, J., Allert, N., Mücke, D., Hermes, A., Meister, IG., Visser-Vandewalle, V., Grice, M., & Timmermann, L. (2017). The Effect of Uni‐and Bilateral Thalamic Deep Brain Stimulation on Speech in Patients With Essential Tremor: Acoustics and Intelligibility. Neuromodulation: Technology at the Neural Interface, 20(3), 223-232. DOI: https://doi.org/10.1111/ner.12546

Dembek, T. A., Reker, P., Visser‐Vandewalle, V., Wirths, J., Treuer, H., Klehr, M., Roediger, J., Dafsari, H.S., Barbe, M.T., & Timmermann, L. (2017). Directional DBS increases side‐effect thresholds—A prospective, double‐blind trial. Movement Disorders, 32(10), 1380-1388. DOI: https://doi.org/10.1002/mds.27093

Kurtis, M. M., Rajah, T., Delgado, L. F., & Dafsari, H. S. (2017). The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence. npj Parkinson's Disease, 3(1), 1-12. DOI: https://doi.org/10.1038/npjparkd.2016.24

Sitz, A., Hoevels, M., Hellerbach, A., Gierich, A., Luyken, K., Dembek, T. A., Klehr, M., Wirths, J., Visser-Vandewalle, V., & Treuer, H. (2017). Determining the orientation angle of directional leads for deep brain stimulation using computed tomography and digital x‐ray imaging: A phantom study. Medical physics, 44(9), 4463-4473. DOI: https://doi.org/10.1002/mp.12424